Expression Kinetics and Mapping of the Thymidine Kinase Transcript and an Immediate-Early Transcript from Channel Catfish Virus

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Expression kinetics and mapping of the thymidine kinase transcript and an immediate-early transcript from channel catfish virus.

Three transcripts from the terminal repeat of the channel catfish virus (CCV; also known as ictalurid herpesvirus 1) genome were mapped by S1 nuclease and primer extension analyses as well as by cDNA sequencing. These transcripts, TR3, TR5/6, and TR6, are encoded by open reading frame (ORF) 3, ORFs 5 and 6, and ORF 6, respectively, and correspond to those previously identified by sequence analy...

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Transcript mapping of the 'early' genes of Orf virus.

The full complement of genes encoded by Orf virus (ORFV) is not yet known. A cDNA library was constructed using mRNA isolated 5 h post-infection from cells infected with ORFV in vitro and grown in the presence of cytosine arabinoside. Using 12 non-overlapping probes representing the entire genome of the Orf-11 strain of the virus, cDNA clones representing individual genes expressed early in inf...

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Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene.

A HeLa cell transient-expression assay system was used to determine if isolated immediate early (alpha) genes from herpes simplex virus (HSV) could transcriptionally activate (transactivate) the type 1 (HSV-1) thymidine kinase (TK) gene [an early (beta) gene]. Cells transfected with the TK gene alone transcribed very low levels of TK RNA. Cells cotransfected with plasmids bearing the sequences ...

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Expression of Thymidine Kinase Messenger RNA and a Related Transcript Is Modulated by Radioprotector WR10651

Previous studies have shown that the radioprotector WR1065 protects against mutagenesis across a wide concentration range (i.e., 40 MMto 4 HIM)but protects against cell killing by ionizing radiation at concentra tions greater than 1 HIM.Other work has demonstrated that many genes are induced or repressed after exposure of cells in culture to ionizing radiation, but the actual inducing agents fo...

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ژورنال

عنوان ژورنال: Journal of Virology

سال: 1998

ISSN: 0022-538X,1098-5514

DOI: 10.1128/jvi.72.5.3900-3906.1998